Synthesis of new pyridine, pyrazole and pyrimidine derivatives of potential antimicrobial effect

Reaction of 2- acetyl tetralin [1] with some aldehydes was conducted in presence of malononitrile and/or ethylcyanoacetate and ammonium acetate, yielded tetrahydronaphthalenyl nicotinonitrile of types 2 and 3. Condensation of 1 with aromatic aldehydes afforded the respective chalcones 4a, b, which yielded pyrazolines 5a, b, phenyl pyrazolines 6a, b, 2-pyrimidinones 7a, b and 2-thiopyrimidines 8a, b upon reaction with hydrazine, phenyl hydrazine, urea, and thiourea, respectively. Some of the synthesized compounds have been screened for their antimicrobial activity against various strains of bacteria and fungi

Studies on the anti-inflammatory and analgesic effects of extracts from marine sponges

Two specimens of sponges collected from Red Sea, Egypt, were investigated for their contents of secondary metabolites. The crude extracts of the sponges were tested for their anti-inflammatory and analgesic effects. The toxic effects of the extracts of the two marine sponges were studied. LD50 determination revealed that the investigated extracts of Iregnella and Ircinia sps were 4.69 and 134.7 mg/100g b.wt. respectively, when injected of intraperitoneally in mice. The toxic signs were recorded within the first 24 hrs after injection. Also the two marine sponges extracts showed significant anti-inflammatory and analgesic effects